Main Street Inn
404 S. Main St., Galena, IL 61036
Vacation Rentals
Located on Galena's historic downtown Main Street, the Main Street Inn is a cozy, inviting place to relax that is listed on the National Register of Historic Places (circa 1850).
Main Street Inn offers 6 luxurious and spacious rooms located on the 2nd floor that will meet the needs of romantic adventures, friend getaways, or anything in between. Walk out the front door to take a stroll up Main Street and browse through Galena's unique stores and boutiques, enjoy dining at one of Galena's fine restaurants, or stop by one of our wine shops. Or stay in and simply enjoy the comforts of your room.
Whatever your reason for coming to Galena, the Main Street Inn is here for you!
What's happening nearby...

Galena St. Patrick's Day Celebration
Downtown Galena • Mar 15 @ 11AM
Celebrate St. Patrick's Day in Galena, Illinois!
Read more about Galena St. Patrick's Day Celebration
Haunted Galena Conference
DeSoto House Hotel • Apr 04 – Apr 06 @ 4PM
Embrace the Darkness with Haunted Galena Tour Company at the haunted DeSoto House Hotel!
Read more about Haunted Galena Conference
Kiwanis River Trail Run
Galena River Trail • Apr 19 @ 10AM
The Kiwanis Club of Galena invites you to sign up for their Annual Run with proceeds benefitting local organizations with supporting children and improving the quality…
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